De Alwis et al. state that vaccines that elicit a Th1 response with a strong T cells response seem to be the best target for a vaccine for SARS-CoV-2.

The importance of targeting SARS-CoV-2 vaccines that elicit a Th1 skewed response

In animal models, the vaccines for coronaviruses that led to a Th1 skewed response demonstrated protection against viral infection and immunopathology. 

Santa Clara University

The vaccines for RSV and measles that resulted in ADE were formalin-inactivated vaccines that led to TH2-skewed responses.

Applying lessons learned from ADE-inducing vaccines to SARS-CoV-2 vaccine development 

de Alwis, R., Chen, S., Gan, E. S., & Ooi, E. E. (2020). Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development. EBioMedicine, 55, 102768. https://doi.org/10.1016/j.ebiom.2020.102768

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