Cross-species transmission of SARS-CoV-2 is a very important factor in spreading the infection. Although we do not have enough evidence of relationships between humans, pets, and domesticated animals, we still need to consider that those animals may be at risk. People living with pets need to take extra precautions, and if they test positive for SARS-Cov-2, they must not have any contact with their pets until they are clear of the virus. Those handling poultry, cows, and other domesticated animals must be careful as well to ensure a one health approach. Because they share the same animal and human cell receptor, Angiotensin-converting Enzyme 2 (ACE2), and there is the potential for this transmission to take place if standard precautions are bypassed.