THH acts as a serotonin reuptake inhibitor (SSRI), similar to many traditional prescribed antidepressants.

Syracuse University

DMT and THH both impact serotonin levels in the brain.

Ayahuasca and Serotonin

Domínguez-clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., De la fuente revenga, M., Friedlander, P., Feilding, A., & Riba, J. (2016). Ayahuasca: Pharmacology, neuroscience and therapeutic potential. Brain Research Bulletin, 126, 89-101. https://doi.org/10.1016/j.brainresbull.2016.03.002


Ayahuasca: Pharmacology, neuroscience and therapeutic potential

THH and Serotonin

DMT is very structurally similar to the endogenous neurotransmitter serotonin (5-hydroxytryptamine; 5-HT). DMT, like other psychedelics has a liking for various serotonin receptors such as 5-HT2A and 5-HT1A, where it acts as an agonist and causes a decrease in serotonergic strength and increases amounts of neural firing through both the excitatory postsynaptic potentials and currents.

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