- it has been suggested that TMPRSS11D and TMPRSS13 both enhance entry of SARS-CoV-2 and subsequent replication
- TMPRSS11D is mainly expressed in the vagina, esophagus, and submucosal serous glands of bronchi and trachea
- TMPRSS13 is mainly expressed in skin, lungs, peripheral blood lymphocytes, and other glandular epithelium cells
- more research needs to be done to discover the role in pathogenicity of SARS-CoV-2

State University of New York at Stony Brook

Other Type II Transmembrane Serine Proteases in the Pathogenesis of COVID-19

Kishimoto, M., Uemura, K., Sanaki, T., Sato, A., Hall, W. W., Kariwa, H., Orba, Y., Sawa, H., & Sasaki, M. (2021). TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein. Viruses, 13(3), 384. https://doi.org/10.3390/v13030384

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