The process in extravasation which leukocytes, in sticking to adhesion molecules and rolling along blood vessel walls near the infection site, bind to more adhesion molecules when near a cellular junction, and squeeze through (exiting the bloodstream)

University of Notre Dame

The process in which leukocytes are able to move across capillaries within tissues. Initiated by complement factor C5a and proinflammatory and chemotactic cytokines released by nearby macrophages and tissues. These components promote the expression of cellular adhesion molecules, which bind to leukocytes and lead to transendothelial migration. Leukocytes then exit the bloodstream and reach the infected areas to begin their pathogen attack. Some leukocytes respond faster than others, with neutrophils responding within hours and monocytes taking up to days.

(Photo credits in References)

Leukocyte: Extravasation (Diapedesis)

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Extravasation Figure (Figure 17.19). Reprinted from OpenStax Microbiology (p. 709), by N. Parker, M. Shneegurt, A.-h. Thi Tu, B. M. Forester, and P. Lister, 2016, Rice University. Copyright 2016 by Rice University.

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