Robinson, K. M. (2024, June 18). First- and Second-Generation Antipsychotics for Schizophrenia. WebMD. https://www.webmd.com/schizophrenia/first-second-generation-antipsychotics

University of North Carolina at Chapel Hill

1st-generation antipsychotics, also known as neuroleptics and conventional antipsychotics, were a 1950s breakthrough. They were made as dopamine antagonists and they seemed to reduce positive symptoms like delusions and hallucinations. These drugs were about 60%-70% effective for people with schizophrenia in reducing their symptoms. The two most popular 1st-generation antipsychotics are Chlorpromazine and Fluphenazine.

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