Peptides produced (usually in liver) and released in response to inflammatory molecules from the immune system. They bind to cell wall of the microbe and increase membrane permeability to kill pathogen. Acute phase proteins are produced by epithelial cells and phagocytes, and provide protection at epithelial surfaces. There are two major families of antimicrobial peptides: defensins and cathelicidins. These include C-reactive proteins, alpha-1 acid glycoproteins, haptoglobulin, fibrinogen, serum amyloid A and complement.

Acute Phase Reactants

A group of plasma protein mediators that contributes to (is part of) the innate immune response as well as connects both innate and adaptive immunity 

Complement System

Types of plasma protein mediators include:
- Acute-phase proteins
- Complement system

University of Notre Dame

Proteins found in blood plasma that contribute to the innate immune response

Plasma Protein Mediators

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