A compensatory increase in receptor availability at the synapse of a neuron with repeated exposure to an antagonist.

Bowdoin College

A molecule that blocks a transmitter from binding with a receptor. These molecules are usually drugs.

Antagonist

Decreased responding to a drug after repeated exposures, generally as a consequence of up- or down- regulation of receptors. 

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

A compensatory reduction in receptor availability at the synapses of a neuron with repeated exposure to an agonist.