1Cademy - Val66Met Polymorphism

Concept

Val66Met Polymorphism

SNP in the BDNF gene resulting in a valine (Val) to methionine (Met) substitution at codon 66 negatively influences activity-dependent release of the BDNF protein, playing an important role in neuroplasticity.
Val66Met SNP reported to be associated with cognitive and emotional dysfunctions by modifying cerebral cortex excitability, gray matter structures, or white matter integrities.
Met-allele carriers, in comparison to Val homozygotes, had gray matter volume deficits found in the temporal, frontal areas, and thalamus.
White matter structural networks of the Met-allele carrier group showed higher vulnerability to targeted removal of central nodes as compared with those of the Val homozygous group.
Increased susceptibility to brain disorders in Met-allele carriers may correlate to the limited stability in white matter structural connectivity.

Updated 2021-10-02

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