The major virulence factor of *Clostridium botulinum* is BoNT which binds to motor neurons. This inhibits neurotransmitter release. This causes paralysis. 

University of Wisconsin - Madison

The bacterium *Clostridium botulinum* produces botulinum neurotoxin, the most lethal biological toxin known, which blocks acetylcholine release in neuromuscular junctions to cause flaccid paralysis. While responsible for rare, often fatal cases of botulism, this toxin is also used in minute doses to treat human muscle pathologies and cosmetically to reduce wrinkles.

*Clostridium botulinum*

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Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology’s art program enhances students’ understanding of concepts through clear and effective illustrations, diagrams, and photographs.

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OpenStax Microbiology Textbook

The characteristic symptom of botulism is loss of muscle activity which causes muscle relaxation and paralysis.

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