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What is now possible with Cryo-EM structures?
- With Cryo-EM improvements, we can solve structures de novo (structure shown below is de novo Cryo-EM structuree of a TRPV1 ion channel that is close to 3 Angstroms).
- Cryo-EM density maps are reminiscent of those from X-ray crystallography. Cryo-EM is clearer because the phase information that is normal lost in X-ray crystallography structures. This makes them clearer than X-ray crystal structures.
- Visualizing small molecule compounds – new resolutions also allow for small molecules to be seen like co-factors and inhibitors.
- the ability to improve the quality protein images is important in so many fields - in combating antibiotic resistance, drug design, and determine mechanisms and functions of proteins.
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Updated 2021-02-01
Tags
Biochemistry
Biomedical Sciences