Genotoxic carcinogens will change the sequence of a cell’s DNA. As we know, DNA is a long chain of repeated molecular units that dictate the growth, function, and development of the cell. DNA sequence changes can lead to problems of uncontrolled growth and later cancer. The non-genotoxic effects of cigarette smoke can also contribute to cancer formation without changing DNA sequencing. changing the sequencing of the DNA. Their mode of transportation can be seen in creating oxidative stress, intercepting hormonal and signal transduction pathways, and epigenetics