- Two molecular signaling molecules that specify dorsal cell fates in the neural tube when in high quantities 

Smith College

- A range of morphogen signaling molecules are used to specify cell identity across the cranial neural tube axis
- This includes Sonic hedgehog (Shh), Wnt, and BMP 

Morphogen Signaling in Cranial Neural Tube 

Brooks, E. R., Islam, M. T., Anderson, K. V., & Zallen, J. A. (2020). Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure. eLife, 9, e60234. https://doi.org/10.7554/eLife.60234

Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

- A molecular signaling molecule that specifies ventral cell fates in the neural tube when in high quantities 
- When in moderate quantities, Shh specifies more median cell fates 
- Involved in cell fate decisions in limb, and gut, as well as the neural tube 

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