The study aims to determine if there is an association between the number of COVID-19 cases and meteorological parameters in select U.S cities. The contribution of temperature and specific humidity on COVID-19 was evaluated using a case-crossover design with a distributed lag nonlinear model. Each COVID-19 case was evaluated on its own control before and after transmission occurred using case-crossover. Looking at eight U.S cities, 5 cities were found have significant relationships while 3 cities did not display significant associations. Overall, there is a small, but positive relationship between humidity and COVID-19 transmission in four cities. Higher COVID-19 transmission were associated with humidity of around 6 to 9 g/kg. Although these results show that weather can have an impact on COVID-19 transmission, more studies need to be done to learn more about the relationship between different meteorological and number of COVID-19 cases.