ACVR1B rs2854464 A allele is associated with increased muscle strength in healthy, non-athletic individuals. The ACVR1B gene encodes a receptor that is essential for signaling.

Michigan State University

The following short sequences of DNA have been used to identify chromosomes that modulate cellular signaling pathways in elite power athletes:

- CREM 
- IP6K3
- TRHR
- ARHGEF28
- ACVR1B
- GPC5
- NRG1
- CLSTN2 
- GABRR1

Genetic Markers Modulating Cellular Signaling Pathways in Elite Athletes

Maciejewska-Skrendo, A., Cięszczyk, P., Chycki, J., Sawczuk, M., & Smółka, W. (2019). Genetic Markers Associated with Power Athlete Status. Journal of human kinetics, 68, 17–36. https://doi.org/10.2478/hukin-2019-0053

Genetic Markers Associated with Power Athlete Status (Reference)

ACVR1B

The CREM A allele of the rs1531550 G/A polymorphism is significantly over-represented in athletes. CREM is important in mediating cAMP signal transduction during the spermatogenetic cycle. It is highly expressed in testis. 

CREM

The IP6K3 gene (location: 6p21.31) rs6942022 C allele is associated with power athlete status. This gene encodes a protein that serves as the second messenger and regulates diverse cellular functions by controlling cellular signaling and interacts with other cellular components. 

IP6K3

The TRHR rs7832552 T allele has been shown to be associated with increased lean body mass. The TRHR gene codes for a receptor that 
 plays a fundamental role in the regulation of metabolic and hormonal functions. 

TRHR

The ARHGEF28 rs17664695 G allele is associated with elite strength athlete status. The protein encoded by the ARHGEF28 gene (location: 5q13.2) promotes control signaling pathways regulating cell proliferation and movement and, in this way, is engaged in cell division and growth.

ARHGEF28

The GPC5 gene (location: 13q32) rs852918 T allele was identified as associated with elite strength athlete status. The proteins encoded by GPC5 are believed to influence the complicated processes of cell division and growth.

GPC5

NRG1 rs17721043 A allele Is associated with power athlete status. The proteins encoded by the NRG1 gene (location: 8p12) have many different functions, and mutations in this gene have been associated with cancer, schizophrenia, and bipolar disorder (BPD).

NRG1

The CLSTN2 rs2194938 C allele as associated with power athlete status. CLSTN2 (location: 3q23) encodes a protein relevant in intracellular post-synaptic signaling.

CLSTN2

The GABRR1 gene (location: 6q15) rs282114 A allele has been found in the group of SNPs that were correlated with power athlete status. GABRR1 encodes one of the major inhibitory neurotransmitter receptors in the central nervous system.

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