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Addictive and Substance-Related Disorders

Addiction is frequently conceptualized as a chronic disease. While the initial decision to use a substance is voluntary, prolonged use can lead to lasting changes in the neural pathways of the prefrontal cortex. This brain region is crucial for judgment and decision-making. The structural alterations caused by substance use can impair these functions, leading to a compulsive drive to use the substance and contributing to high rates of relapse.

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Updated 2025-10-10

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