Nonhuman primates (NHPs) successfully model respiratory viral infections in humans because of the vast similarities to human respiratory anatomy and immunology. Historically, NHP species have been used to model pathogenesis and develop vaccines. NHPs are vulnerable to infection and develop moderate SARS-CoV-2 disease phenotypes; however, prior studies have not been able to replicate severe infections and ARDS. Experiments performed by Tulane National Primate Research Center have observed ARDS in older RMs and AGMs that were infected with SARS-CoV-2.