While many animals have been used in laboratory studies of SARS-CoV-2, no model has been created that replicates the severity of the disease similar to hospitalized COVID-19 patients. In order to reduce COVID-19 morbidity and mortality, a reliable animal model is necessary to understand the biology of the infection as well as possible interventions. Animal models that produce severe infections, specifically pathogenesis of Covid-19 induced ARDS, are neccesary to develop reliable therapeutics.

Potential animal models include:

• K18-hACE2 Mice
• AAV-hACE2 Mice
• HFH4-hACE2 Mice
• African Green Monkeys
• Rhesus Macaques