SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function
Winkler, E. S., Bailey, A. L., Kafai, N. M., Nair, S., McCune, B. T., Yu, J., ... & Ritter, J. H. (2020). SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function. bioRxiv. https://www.biorxiv.org/content/10.1101/2020.07.09.196188v1 doi: 10.1101/2020.07.09.196188
0
1
Tags
SARS-CoV-2 (COVID-19)
Biomedical Sciences
Related
The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells.
Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex
SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function
SARS-CoV-2 Spike protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia
ACE2-independent interaction of SARS-CoV-2 spike protein to human epithelial cells can be inhibited by unfractionated heparin
FDA approved calcium channel blockers inhibit SARS CoV 2 infectivity in epithelial lung cells
Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise
SARS-CoV-2 infects brain choroid plexus and disrupts the blood-CSF-barrier