HCov-229E

It is among the four identified coronaviruses which are known to continuously circulate in the human population, especially in young children. HCoV-NL63 was first isolated in Amsterdam in 2004 from the nasopharyngeal aspirate of a seven-month old child; the patient presented with symptoms suggesting respiratory tract infection (coryza, conjunctivitis, and fever), while his chest X-ray showed typical features of bronchiolitis

HCov-NL63

University of Michigan - Ann Arbor

The viruses were firstly divided into these genera based on serology but are now grouped by phylogenetic clustering.
1. alpha
2. beta
3. gamma
4. delta

 Main sub-groupings of coronaviruses

Ogimi, C., Kim, Y. J., Martin, E. T., Huh, H. J., Chiu, C. H., & Englund, J. A. (2020). What’s New With the Old Coronaviruses?. Journal of the Pediatric Infectious Diseases Society.
https://academic.oup.com/jpids/advance-article/doi/10.1093/jpids/piaa037/5823148

What’s New With the Old Coronaviruses?

Alpha coronaviruses

Genomic organization of representative α, β, and γ CoVs

1. HCoV-HKU1
2. HCoV-OC43 
3. HCoV-NL63
4. HCoV-229E
5. MERS-CoV 
6. SARS-CoV
7. SARS-CoV-2

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