Other studies recently published have demonstrated the progression of SARS-CoV-2 in AGMs and RMs. Both animals are capable of modeling mild to moderate disease and can be used to analyze the efficacy of vaccines and other therapeutics. However, these other studies have not demonstrated the clinical manifestation, ARDS, of the Covid-19 infection. Results of this study show that aged AGMs infected with Covid-19 can develop ARDS (signified by cytokine elevations similar to those in humans). The study’s findings are associated with the results from other studies, with AGMs presenting mild clinical disease, pathology and viral shedding.