In this study performed by the Tulane National Primate Research Center, reports of physiological symptoms similar to patients with severe infections of SARS-CoV-2 were confirmed. Two cases of ARDS in African green monkeys (AGMs) and mild infections in 2 AGMs and 4 RMs infected with Covid-19 were observed. All the AGMs had increased levels of plasma IL-6 and three of the four infected AGMs had high levels of circulating cytokines. All of these factors indicate an immune response similar to those in humans and support the use of AGMs as animal models useful for observing the in vivo effects of ARDS.