Neglected tropical diseases disproportionately affect the world’s poorest populations or the “bottom billion”, a total 1.4 billion people living below the poverty level. These populations suffer from bacterial, protozoal, viral and helminthic infections which include chagas disease, hookworm, dengue fever and schistosomiasis. These diseases contribute to poverty as they adversely affect child cognitive development and worker productivity, thus promoting a generational cycle of poverty. Vaccines that target these childhood and neglected diseases are referred to as “Anti-Poverty Vaccines”. Although vaccine development that target childhood diseases have overcome efforts to combat NTDs, development and delivery of NTD vaccines have currently become financially incentivized. However, further stimulation of large pharmaceutical companies and vaccine distributors is needed to promote vaccine development for NTDs.