Antipsychotics are a class of psychiatric medications that are used to manage symptoms of psychosis such as hallucinations, delusions, and disorganized thinking, and are commonly prescribed for conditions such as schizophrenia and bipolar disorder. They usually work by antagonizing D2 dopamine receptors. However, low threshold responders often experience amplified side effects or poor tolerability even at standard or reduced doses, which may make treatment more harmful than helpful. These reactions are usually caused by genetic polymorphisms affecting dopamine and serotonin receptor function or drug-metabolizing enzymes.