Coronary-artery aneurysms are a common feature of KD, affecting approximately one quarter of patients. However, in a study of 186 pediatric patients with MIS-C in 26 states, coronary-artery aneurysms were only documented in 15 patients (8%).

Coronary-artery Aneurysms in MIS-C and Kawasaki's Disease (KD)

In a study of 186 pediatric patients with MIS-C in 26 states, cardiovascular involvement leading to vasopressor or vasoactive support was observed most frequently in older children and adolescents. About 5% of children with KD in the United States present with cardiovascular shock leading to support, compared with 50% of the MIS-C patients in this study. 

Bowdoin College

In a study of 186 pediatric patients with MIS-C in 26 states, KD–like features were documented in 74 patients (40%), but 60% of those patients would not have met the complete or incomplete criteria for KD. KD usually affects children under the age of 5. On the other hand, MIS-C has been suggested to affect adolescents and children older than 5 years old. MIS-C also has different cardiovascular involvement compared with KD.

Comparing Kawasaki Disease (KD) and MIS-C

Feldstein, L. R., Rose, E. B., Horwitz, S. M., Collins, J. P., Newhams, M. M., Son, M. B., ... Randolph, A. G. (2020). Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. New England Journal of Medicine, 383(4), 334-346. doi:10.1056/nejmoa2021680

https://www.nejm.org/doi/full/10.1056/NEJMoa2021680?query=featured_coronavirus

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