Binds to the 50S ribosomal subunit to prevent peptide bond formation and stop protein synthesis

University of Southern Mississippi

- Chloramphenicol
- Macrolides
- Lincosamides
- Tetracycline
- Aminoglycosides
- Oxazolidinones

Major classes of Protein Synthesis Inhibitors

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Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology’s art program enhances students’ understanding of concepts through clear and effective illustrations, diagrams, and photographs.

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OpenStax Microbiology Textbook

Chloramphenicol

Blocks peptide bond formation between amino acids on the ribosomal 50S subunit

Macrolides & Lincosamides

Blocks the binding of tRNA's with the 30S ribosomal subunit

Tetracycline

Causes mismatches between codons and anticodons leading to faulty proteins that insert and disrupt the cytoplasmic membrane

Aminoglycosides

Interferes with the formation of the initiative complex between 50S and 30S subunits and other factors

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