Inhibition of RAS in diabetic neuropathy 

California Baptist University

Research has highlighted the concept that depression, stroke, and cognitive dysfunction might be representations of cerebral microvascular disease. Some of the risk factors for this are hyperglycemia, insulin resistance, dsylipidemia, and hypertension. These are also the main risk factors for DPN. It has been found that cognitive dysfunction are commonly found in people with DFU, who also might have DPN. 

Association of Cognitive Dsyfunction and Vascular Brain Disease

References for Diabetic Peripheral Neuropathy and Depression: Dancing with Wolves? - Mini-Review and Commentary on Alghafri et al. “Screening for depressive symptoms amongst patients with diabetic peripheral neuropathy”

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