After 12 weeks of treating patients with major depressive disorder (MDD) and that had reported forms of childhood trauma (i.e., physical and/or sexual abuse, neglect, and the loss of a parent(s) at a young age) with cognitive behavioral analysis system of psychotherapy (CBASP), the effects of this therapy alone was more effective than nefazdone alone. Moreover, 43.8% of patients with MDD and reported childhood trauma achieved remission of depression with therapy alone after the study.