The contrasting responses patients produce to psychotherapy and pharmacotherapy indicates that there could be critical variation in the origin/cause and development of chronic depression in people with or without childhood trauma. Additionally, psychotherapy's superiority to pharmacotherapy when administered alone suggests its beneficial results.

Why forms of Psychotherapy is essential to treating patients with chronic forms of major depression and childhood trauma

After 12 weeks of treating patients with cognitive behavioral analysis system of psychotherapy and nefazodone (antidepressant), the effects of this treatment design was only slightly superior to psychotherapy alone. Moreover, 53.9% of patients with MDD and reported childhood trauma achieved remission of depression with combination therapy after the study.

University of Illinois at Chicago

After 12 weeks of treating patients with major depressive disorder (MDD) and that had reported forms of childhood trauma (i.e., physical and/or sexual abuse, neglect, and the loss of a parent(s) at a young age) with cognitive behavioral analysis system of psychotherapy (CBASP), the effects of this therapy alone was more effective than nefazdone alone. Moreover, 43.8% of patients with MDD and reported childhood trauma achieved remission of depression with therapy alone after the study. 

Cognitive Behavioral Analysis System of Psychotherapy's (CBASP) efficacy on Major Depressive Disorder in patients with childhood trauma

Nemeroff, C. B., Heim, C. M., Thase, M. E., Klein, D. N., Rush, A. J., Schatzberg, A. F., ... & Keller, M. B. (2003). Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. Proceedings of the National Academy of Sciences, 100(24), 14293-14296.

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