The contrasting responses patients produce to psychotherapy and pharmacotherapy indicates that there could be critical variation in the origin/cause and development of chronic depression in people with or without childhood trauma. Additionally, psychotherapy's superiority to pharmacotherapy when administered alone suggests its beneficial results.

University of Illinois at Chicago

After 12 weeks of treating patients with cognitive behavioral analysis system of psychotherapy and nefazodone (antidepressant), the effects of this treatment design was only slightly superior to psychotherapy alone. Moreover, 53.9% of patients with MDD and reported childhood trauma achieved remission of depression with combination therapy after the study.

Combination therapy effects on patients with Major Depressive Disorder and childhood trauma

Nemeroff, C. B., Heim, C. M., Thase, M. E., Klein, D. N., Rush, A. J., Schatzberg, A. F., ... & Keller, M. B. (2003). Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. Proceedings of the National Academy of Sciences, 100(24), 14293-14296.

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