Researchers implement mathematical models to investigate deep level cognitive impairments in schizophrenic individuals.

Theory Driven Approach 

- Disturbed excitatory-inhibitory balance due to disrupted glutamate signaling may contribute to working memory deficits 
- Reduced GABAergic activity in the visual cortex as well as a disturbed connection between the lateral geniculate nucleus and the visual cortex may contribute to visual perceptual abnormalities


Findings from Computational Modeling

A neurocomputational model which can be utilized to explain perceptual abnormalities in schizophrenic individuals.

Predictive Coding

Researchers employ tools from computational neuroscience to understand the underlying mechanisms of cognitive impairments in schizophrenia.

Saint Louis University

- Neuroinflammation and Cognition
- Computational Modeling of Cognitive Processes 
- Cognition and Remote Digital Technology 
- Brain Network Organization 



Future Directions for Research on Cognition in Schizophrenia 

American Psychiatric Association . (n.d.). What is Schizophrenia? What is schizophrenia? Retrieved January 27, 2022, from https://www.psychiatry.org/patients-families/schizophrenia/what-is-schizophrenia 

What Is Schizophrenia?

Peripheral inflammation and increased central immune system activation have been linked to poorer cognition function in individuals suffering from schizophrenia. However, the results from these studies are mixed and cannot provide conclusive evidence.

Neuroinflammation and Cognition

Computational Modeling of Cognitive Processes


Regarding schizophrenia, the benefits of cognitive assessment via remote technology is uncertain.

Cognition and Remote Digital Technology 


According to researchers’ findings, many characteristics of schizophrenia, specifically cognitive functioning, can be linked to an underlying problem in neural connectivity.


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