Researchers implement mathematical models to investigate deep level cognitive impairments in schizophrenic individuals.

Saint Louis University

Researchers employ tools from computational neuroscience to understand the underlying mechanisms of cognitive impairments in schizophrenia.

Computational Modeling of Cognitive Processes


American Psychiatric Association . (n.d.). What is Schizophrenia? What is schizophrenia? Retrieved January 27, 2022, from https://www.psychiatry.org/patients-families/schizophrenia/what-is-schizophrenia 

What Is Schizophrenia?

Theory Driven Approach 

- Disturbed excitatory-inhibitory balance due to disrupted glutamate signaling may contribute to working memory deficits 
- Reduced GABAergic activity in the visual cortex as well as a disturbed connection between the lateral geniculate nucleus and the visual cortex may contribute to visual perceptual abnormalities


Findings from Computational Modeling

A neurocomputational model which can be utilized to explain perceptual abnormalities in schizophrenic individuals.

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