Caregiving moderates the course of the disorder in young children, but some children, even after placement in a more stable environment, still show symptoms through adolescence and adulthood.

New Mexico Highlands University

Risk and prognostic factors of the disorder include:
- Temperamental
- Environmental
- Genetic and Physiological
- Course Modifiers

Risk and Prognostic Factors of Disinhibited Social Engagement Disorder 

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed., Text revision). https://doi.org/10.1176/appi.books.9780890425596

DSM-5-TR

In foreign adoptees in the United States, reduced reward sensitivity and less inhibitory control is correlated with nonselective social behavior.

Temperamental Factors of Disinhibited Social Engagement Disorder 

Social neglect is required for this disorder to be diagnosed, as a strong correlation was found among the two. Other factors related to this diagnosis include multiple placements, having a mother with borderline personality disorder, atypical caregiving, and low quality of care. The disorder has not been found in children who are socially neglected past age 2. In many situations, the disorder continues, even if the children’s caregiving is significantly improved.

 Environmental Factors of Disinhibited Social Engagement Disorder

There’s preliminary findings on neurobiological factors connected to symptoms of the disorder.

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