The Down syndrome community was highly impacted by the COVID-19 pandemic; disproportionately impacted compared to typically developing people. A study from the American College of Physicians Public Health Emergency Collection reported that individuals with Down syndrome have a 4 fold increased risk for COVID-19 related hospitalization and a 10 fold increased risk in COVID-19 related mortality. The study discusses that the various health comorbidities of Down syndrome cause individuals with Down syndrome to have predispositions to other respiratory infections and diseases.