1Cademy - CQ and HCQ Roles In Fighting SARS-CoV-2

Relation

CQ and HCQ Roles In Fighting SARS-CoV-2

Inhibits N-glycosylation to prevents ACE2 receptors from binding onto the surface of the host cell
Prevents maturation of the viral spike proteins, which includes SARS-CoV-2, by inhibiting N-glycosylation
CQ/HCQ prevents buildup of sialic acid, which is responsible for viral entry
CQ inhibits PICALM action, decreasing viral entry
In SARS-CoV-2, CQ/HCQ inhibits viral entry after the onset of the virus
CQ may be able to prevent TGN vesicles from transporting the virus into the lungs (observed in the Chikungunya virus)
CQ prevents p38 MAPK from spreading the virus to the respiratory tract
There was not a significant variation between the cytotoxicity of CQ and HCQ
CQ may be more efficient at inhibition viral action compared to HCQ
CQ and HCQ inhibit the maturation of endocytotic cells to transport the viral particles into the cell