CQ is a better treatment option for COVID-19 compared to Ritonavir. However, HCQ and azithromycin should not be combined when treating COVID-19 patients. It was found that the effectiveness of HCQ was greater in those presenting with symptoms.


Michigan State University

- CQ and HCQ prevent the release of prostaglandins, which are known to cause inflammation; this, in turn, prevents damage to tissue
- CQ prevents thrombin formation
- CQ inhibits phospholipase A2, which is known to cause viral replication in SARS-CoV-2
- CQ/HCQ decreases the presence of platelets
- HCQ prevents endothelial damage
- As a result of anti-inflammation due to CQ and HCQ, it is possible for a decrease in iron levels
- HAMP production is decreased when cytokines responsible for inflammation are decreased


CQ and HCQ Action in Prevention of COVID-19

Roldan, E. Q., Biasiotto, G., Magro, P., & Zanella, I. (2020). The possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): A role for iron homeostasis?. Pharmacological Research, 104904.

The possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): A role for iron homeostasis?

Learn Before

Related