- deep sequencing was used to sequence B cell receptor repertoires from COVID-19 patients
- It was found that there were similar immune signatures across the board, raising the question of severity of infection impacts immune response
- This is critical when looking at immune responses across various demographics and when trying to summarize the mechanisms of SARS-CoV-2 infection

Michigan State University

- Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures
-  Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?

Deep sequencing

Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK, Dias J, James LK, Thomas G, Lee W-YJ, Betley J, Cavlan O, Leech A, Deane CM, Seoane J, Caldas C, Pennington DJ, Pfeffer P and Osbourn J (2020) Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures. Front. Immunol.

Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures

- deep sequencing was used to determine that the endoplasmic reticulum could be a potential therapeutic target
- In a time where treatment options for COVID-19 patients are incredibly limited and primitive, being able to gain insight on potential therapeutic targets is invaluable
- In addition, being able to identify targets in general is another great power of deep sequencing

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