When individuals have medical conditions and take medications, clinicians should consider whether mood symptoms are caused by the medical condition itself or the medication. The patient's history is crucial for making this determination. Adjustments in medical treatment may be needed to determine the causative agent. If both substance use or withdrawal and another medical condition contribute to the disturbance, both diagnoses may be given. When there is insufficient evidence to attribute the symptoms to substance use, another medical condition, or if they are independent, a diagnosis of other specified depressive disorder or unspecified depressive disorder is used.