Concept

Discussion for Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents in New York City

Features overlapped with, but were distinct from, those of KD and TSS. The observed pattern of cytokine expression suggests an interferon signaling component, along with IL-6 and IL-10 production, seen in KD5 and acute pulmonary COVID-19 infection. The lack of elevated TNF-α or IL-13 levels may differ from acute pulmonary COVID infections. The occurrence of abnormal cardiac findings suggests the need for long-term surveillance. Limitations include the small number of patients, short follow-up period, and the inability to establish causality.

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Updated 2020-06-15

Tags

SARS-CoV-2 (COVID-19)

Biomedical Sciences