Cannabis use disorder involves the problematic use of substances derived from the cannabis plant or synthetic compounds with similar effects. The primary psychoactive component responsible for addiction is delta-9-tetrahydrocannabinol (THC). Cannabis affects the brain by interacting with CB1 and CB2 cannabinoid receptors. Cannabis is consumed in various forms, including smoking (joints, pipes, blunts), vaporizing (vaping), dabbing (inhaling concentrated cannabis products), and ingestion (edibles, beverages). Cannabis potency varies greatly, and its potency has been increasing over time. Synthetic cannabinoids have unpredictable effects and can be more harmful than cannabis.