LSD was found to have a potent inhibitory effect upon tonically firing 5-HT neurons in the raphe nucleus. Inhibition was observed through direct action in the somatodendritic region of 5-HT neurons. Indoleamines have also been seen to inhibit these serotonin neurons in the same nuclei. LSD is potent in its agonist abilities at the 5-HT1A autoreceptors accounting for inhibitory effects on Raphe Neurons. It was seen that mescaline and phenethylamines don't have an affinity for these receptors. The actions of LSD are similar to other drugs, like buspirone, known to have anxiolytic effects.