Obese and diabetic people
 - have uncontrolled blood glucose levels 
- have a greater risk to develop severe COVID-19 infection 
- COVID-19 causes cytokine storm 
- May be associated with dysfunctional adaptive immune response and epithelial cell death. 


Background 

Elevated glucose level and sustained aerobic glycolysis in monocytes directly promote:
- viral replication
- cytokine production
- T cell dysfunction and lung epithelial cell death 


Results 

Targeting metabolic pathways may provide new therapeutic strategies to treat COVID-19 disease.


Conclusion 

COVID-19 is more severe in Diabetic people


Northwestern University

Diabetes in elderly patients is a factor in the high rates of mortality for COVID-19 victims. Patients with diabetes or hypertension have an increased risk of having a severe case of COVID-19 or needing an ICU admission immediately. Infection of SARS-CoV-2 in diabetic patients triggers higher stress conditions which can increase blood glucose levels and cause unusual glucose fluctuation. Many of the elderly patients in Wuhan with diabetes are hypoglycemic. 

COVID-19 and diabetes: Knowledge in progress


Campos Codo, A. Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis https://pubmed.ncbi.nlm.nih.gov/32697943/. 

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