- SARS-Cov-2 infection produce reactive oxygen species (ROS)
- ROS induce HIF1a (hypoxia induced Factor-1a)
- HIF1a induce transcription of proinflammatory cytokines
- Increased PD-1, IL-1, IL-6, TNFa
- Decreases anti-inflammatory cytokines 
- Decreased IFNg
- Increases epithelial cell death
- Decreased T cell proliferation

SARS-CoV-2 induces cytokine storm

Elevated glucose level and sustained aerobic glycolysis in monocytes directly promote:
- viral replication
- cytokine production
- T cell dysfunction and lung epithelial cell death 


Northwestern University

COVID-19 is more severe in Diabetic people


Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

Obese and diabetic people
 - have uncontrolled blood glucose levels 
- have a greater risk to develop severe COVID-19 infection 
- COVID-19 causes cytokine storm 
- May be associated with dysfunctional adaptive immune response and epithelial cell death. 


Background 

Results 

Targeting metabolic pathways may provide new therapeutic strategies to treat COVID-19 disease.


Learn Before

Related

Learn After