The elevated plus maze is used to evaluate anxiety-like behaviors in rodents. Subjects are placed in the junction of the maze, and their entries into either the open arms or the closed arms are recorded over a set duration. Unlike traditional methods of measuring anxiety in rodents, such as food deprivation or shocks, the elevated plus maze does not present a noxious stimuli and therefore does not lead to aversive conditioning. Wild-type rodents gravitate toward the dark, enclosed arms of the maze; however, anti-anxiety behaviors can be induced in these rodents (i.e. administration of anxiolytics), which can be strongly correlated to more time spent in the light, exposed arms of the maze.