The Enteric Nervous System is a subset of the Autonomic Nervous System. It controls the gastrointestinal functioning. It is also called the " second brain" as it can function independently of the brain and spinal cord, although it can be influenced by them. Being imbedded in the gastrointestinal tract from the oesophagus to the anus, it controls the motor functioning of the G.I tract along with controlling the secretions of the gastrointestinal enzymes. The neurons of ENS are embedded into two types of ganglia: Myenteric Plexus and Submucosal Plexus. The myenteric plexus is embedded between the inner and outer layer of muscularis externa (layer of smooth muscles). The submucosal plexus is embedded in the submucosal layer.