The specific brain abnormalities seen in epilepsy may explain the relationship of epilepsy, suicidality, and the high occurrence of disruptive (ADHD, oppositional defiant disorder, and conduct disorder) and emotional psychiatric disorders. Compared to healthy youth, children with epilepsy have decreased orbital-frontal volumes, as these abnormalities in this region of the brain are associated with the emotional dysregulation that leads to suicide behaviors, depression, and impulsivity.