- According to a Wuhan MedRxiv article, SARS-CoV-2 antibodies do not last long enough to make herd immunity or vaccines a likely solution. Additionally, SARS-CoV Ab therapies may not be applicable to SARS-CoV-2
-  antibody dependent enhancement (ADE) is of concern as a recent study on NAbs against MERS-CoV RBD has shown ADE
- some SARS-CoV-2 S mutations may be resistant to RBD-targeting NAbs (E484, F490, Q493, and S494)

Northwestern University

State University of New York at Stony Brook

-  Support for the use of SARS-CoV-2 Ab for therapies
-  Evidence suggesting SARS-CoV-2 Ab may not be the most viable solution

SARS-CoV-2 Antibodies and their uses in future SARS-CoV-2 Therapies

This MedRxiv Paper fully titled "Prevalence of IgG antibodies to SARS-CoV-2 in Wuhan–implications for the ability to produce long-lasting protective antibodies against SARS-CoV-2" investigates how long antibodies against SARS-CoV-2 last in the body.

-  Found that IgG prevalence increased significantly by age among healthcare workers and general workers, but that otherwise rates were low. Very few healthcare providers had IgG antibodies to SARS-CoV-2, though a significant proportion of them had been infected with the virus. After SARS-CoV-2 infection, people are unlikely to produce long-lasting protective antibodies against this virus.
-  Has significant implications for herd immunity, antibody-based therapeutics,
public health strategies, and vaccine development.
-  Also has findings that refute the possibility of using SARS-CoV anitbody therapies for SARS-CoV-2

https://www.medrxiv.org/content/10.1101/2020.06.13.20130252v1.full.pdf

Prevalence of IgG antibodies to SARS-CoV-2 in Wuhan–implications for the ability to produce long-lasting protective antibodies against SARS-CoV-2

Huang, Y., Sun, H., Yu, H., Li, S., Zheng, Q., & Xia, N. (2020). Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective. Antibody Therapeutics, 3(4), 285-299.
https://doi.org/10.1093/abt/tbaa028

Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective 

- prior evidence for SARS- CoV, MERS-CoV and influenza have shown that convalescent plasma transfusion is effective against infectious diseases
- multiple researches has shown that NAbs are robust as a therapeutic potential against COVID-19
- NAb CB6 has demonstrated strong viral inhibition in nonhuman primates
- cocktail antibodies have been suggested as more efficient

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