High concentrations of Type I IFN may be destructive to certain body systems in mammals, triggering an inflammatory response to a nonexistent viral infection. In fact, raised levels of type I IFN are reported in autoimmune diseases, such as systemic lupus erythematosus (SLE). 

Tulane University

Type I IFN is produced by cells in response to an intracellular viral infection, blocking reinfection of the virus. Multiple forms of IFN exist, evidenced by the 17 genes located on chromosome 9p. A significant factor of the cellular antiviral response induced by type I IFN, is the expression of interferon stimulated genes (ISGs). A multitude of ISGs have been identified and their relation to interferon signatures has been published numerous times. However, there is little information about the genes products of ISGs and their antiviral properties, signaling cascades and specificity. 

ISG Expression & Type I IFN Signaling

Rice GI, Forte GM, Szynkiewicz M, Chase DS, Aeby A, Abdel-Hamid MS, Ackroyd S, Allcock R, Bailey KM, Balottin U, Barnerias C, Bernard G, Bodemer C, Botella MP, Cereda C, Chandler KE, Dabydeen L, Dale RC, De Laet C, De Goede CG, Del Toro M, Effat L, Enamorado NN, Fazzi E, Gener B, Haldre M, Lin JP, Livingston JH, Lourenco CM, Marques W Jr, Oades P, Peterson P, Rasmussen M, Roubertie A, Schmidt JL, Shalev SA, Simon R, Spiegel R, Swoboda KJ, Temtamy SA, Vassallo G, Vilain CN, Vogt J, Wermenbol V, Whitehouse WP, Soler D, Olivieri I, Orcesi S, Aglan MS, Zaki MS, Abdel-Salam GM, Vanderver A, Kisand K, Rozenberg F, Lebon P, Crow YJ. Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. Lancet Neurol. 2013 Dec;12(12):1159-69. doi: 10.1016/S1474-4422(13)70258-8. Epub 2013 Oct 30. PMID: 24183309; PMCID: PMC4349523.

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study

Learn Before

Related