Type I IFN is produced by cells in response to an intracellular viral infection, blocking reinfection of the virus. Multiple forms of IFN exist, evidenced by the 17 genes located on chromosome 9p. A significant factor of the cellular antiviral response induced by type I IFN, is the expression of interferon stimulated genes (ISGs). A multitude of ISGs have been identified and their relation to interferon signatures has been published numerous times. However, there is little information about the genes products of ISGs and their antiviral properties, signaling cascades and specificity.