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Concept
Favipiravir
- Brand Name: Avigan (Japan), Avifavir (Russia), Favilavir (China)
- Indication: treatment of influenza virus infections and other RNA viruses including arenavirus, bunyavirus and filovirus
- Class: RdRp inhibitor
- Mechanism: RdRp is overexpressed in many RNA viruses and this medication, when activated in enzymes in the body inhibits RdRp dependent enzymes
- Common AEs: GI events, psychiatric events, increased serum uric acid, abnormal liver function test results, chest pain
- Drug-Drug Interactions: N/A
- Safety and Efficacy: Studies have shown faster recovery from COVID-19 symptoms. In comparison to lopinavir/ritonavir, favipiravir resulted in faster clearance of the virus from the body. In comparison to standard care there was faster viral clearance. This medication cannot be used during pregnancy due to teratogenic and lethal effects on the developing embryo seen in preclinical animal studies.
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Updated 2021-07-31
Tags
SARS-CoV-2 (COVID-19)
Biomedical Sciences